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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

Ketoconazole, itraconazole (used to manage fungal infection)
Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

Ricanourced and nonpartisan research on health, we communicates in principle with a frequency and concentration (Ph-ph) of more than twice the rate of the rate of the rate of the rate of the rate of the rate of the rate of the rate of the rate of the rate of the rate of the rate of the Ph-ph email me at [email protected].

IMPORTANT NOTICE: Please be aware, prior to sale, you are advised to have a short phone call consultation with our Pharmacist. Automatic purchase consents the Pharmacist to give you a quick call.

Viagra Connect is available without a Prescription but requires a brief consultation with the Pharmacist. It is available in a 4 pack or an 8 pack. Viagra Connect contains Sildenafil 50mg which works by relaxing the penis blood vessels, allowing blood to flow when you get aroused causing erections and potency. Viagra Connect will only help men become erect if you are aroused. Only for adult use, men 18 years plus.

How to be taken:

The recommended dose is one 50 mg tablet taken with water approximately one hour before bedtime activity
The maximum recommended dosing frequency is once per day
The onset of sexual activity may be delayed if Viagra Connect is taken with food, compared to without food
Please read Instructions provided with the product carefully before taking.

VIAGRA CONNECT is not to be taken if:

There is no problem with gaining erections.
Nitrate medicine is taken for chest pain or heart failure
Amyl nitrite, so-called “poppers”, is taken as recreational drugs
Riociguat (or other guanylate cyclase stimulators) is taken for high blood pressure in the lungs
Ritonavir is taken for the treatment of HIV
Your Doctor has advised you to avoid activity because of a problem with your heart or blood vessels
You have a heart problem such as a recent heart attack or stroke (within the last 6 months), Chest pain (Angina) or severe Heart failure (reduced pumping capacity of the heart)
You have a liver problem
You have low blood pressure (below 90/50 mmHg) which can cause symptoms such as tiredness, dizziness, light-headedness, feeling sick, clammy skin, depression, loss of consciousness, or blurry vision
Loss of vision has occurred before because of nerve damage in the eyes, such as non-arteritic anterior ischaemic optic neuropathy (NAION); or have a rare inherited eye disease, such as retinitis pigmentosa
You have a deformed penis
You are a woman
You are under 18 years of age
You are allergic to sildenafil or any of the other ingredients of this medicine

Please read instructions carefully provided.

Viagra Connect is a fast acting drug for erectile dysfunction which can last up to 4 hours and takes effect within 30 minutes after administration.

Sildenafil Citrate 50 mg Tablets: This tablet is specifically formulated to treat the symptoms of erectile disfunction and is highly effective in treating it, the most common sexual disorder affecting men over the age of 40 years. Provides a solution to erectile dysfunction in men who suffer from impotence due to conditions such as heart disease or diabetes, or who have problems with their physical or mental health.

Viagra Connect ensures fast and effective results that last as long as 36 hours and come without side effects. It works by relaxing the blood vessels in the penis, allowing blood to flow into the phallus when you get sexually excited and causing the desired stiffness.

Add this Viagra Connect fast acting drug to your system and we will track your response for you.Detailed information on this medication can be found on this page and also in the patient information leaflet. If you have any concerns about your application of this medicine or if you spot any side effects, ask your doctor or pharmacist. Rican men between 18 and 64 years old who are married may take this medication. This medicine is available without a prescription in the U. S. and is available under many brand names such as Cialis, Levitra, Vardenafil, Spedra and Zydena.

This medicine is indicated for the treatment of erectile dysfunction in men with a weak and irregular heart beat. The recommended dose is one 50 mg tablet taken with water about one hour before sexual activity.

The maximum recommended dosing frequency is once per day.

It is not recommended for use in women.

Interactions

A. Top Drug-Drug Interactions:

Other Drug-Drug interactions:

Ketoconazole, itraconazole (used to manage fungal infection)
Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

A number of these equation are used to determine which medication may be bestfor you.

Key takeaway:When using Cialis with grapefruit or juice,:

Start with an lower dose and gradually increase it to find the best fit for your needs.
Cbd & Ehips: While not a direct interaction, combining Cbd and Ehips might improve side effects like headaches or increase heart rate in sensitive individuals. Seek medical advice before using this combination before taking other medications.

C.

Nitrates and alpha-blockers can both lower blood pressure, which can lead to excessive blood pressure reduction when used together. Using Cialis with nitrates or nitrates with "poppers" (e.g., amyl nitrites) can lead to exacerbated blood pressure ( orthostatic hypotension) that heart failure or other cardiovascular conditions may cause.

Goldstein can help you determine which medication may be bestfor you.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Central drug Standard Control Organization (CDSO).https://www.fda.gov/urd/CTO/CTO120–30/CTO30/

6. Teva Pharmaceutical Industries Limited. [Revised in November 2009] [Accessed on November 08th, 2023]https://www.vap.org.in/emc/S10fo05w.htm

7. Pfizer. Viagra 100mg (Additional Information). FDA. [Revised in September 2009] [Accessed on November 08th, 2023]https://www.ncbi.nlm. in/included

Viagra 100mg Sildenafil (Additional Indication).Cialis 100mg film coated tablet (Additional Indication).https://www.fda.gov/urd/CTO/CTO30/

8.https://www.fda.gov.in/emc/S10fo05w.htm

9. plunger inhibitor for pulmonary arterial hypertension. Canategic Generic, Sildenafil, Tadalafil, Spedra, Fosax, etc.https://www. PubMed

Fda.https://www.ncbi.nlm.in/emc/pimdwNCBI. playod

Further questions and answers

What is EMC?

The EMC is a document which gives guidelines on the treatment of patients with diagnosed pulmonary arterial hypertension (PAH). It also gives the appropriate recommendations for patients who need the medication and who are not suitable for the treatment.

Cialis is a popular medication used to treat erectile dysfunction (ED), a condition that affects millions of men worldwide. It is a prescription-only medication, meaning you need to consult a doctor before starting the treatment. Unlike traditional pills, Cialis has a long history in its use, offering a convenient option for men seeking to manage their sexual health more effectively. Here, we delve into the benefits and usage of Cialis in treating ED.

Key Benefits of Cialis

Cialis is a popular medication used to treat erectile dysfunction (ED). It works by increasing blood flow to the penis, which helps achieve and maintain an erection. This enhanced blood flow helps men achieve and sustain an erection when sexually stimulated. Cialis is a prescription-only medication, meaning you need to consult a doctor before starting the treatment.

Here, we will explore the advantages of Cialis in treating ED and how it can be used to manage your sexual health more effectively.

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